Cryopreserved animal Hepatocytes

Cryopreserved animal Hepatocytes

We offer a selection of cryopreserved hepatocytes from toxicologically-relevant species: e.g. monkey, rat and mouse.

A CoA for each lot specifies qualification, such as short- or long-term as sandwich or as 3D-spheroid culture, biliary canaliculi formation, metabolic phase I and II drug metabolizing enzyme activity, response to specific inducers… 

Advantages of using KaLy-Cell's products:

All preparations are made and characterized according to Standard Operating Procedures.

Quality is governed by the assigned Product Study Director and KaLy-Cell's Quality Assurance.

Our commitment to ethics

KaLy-Cell fully supports the ethical use animal tissues. KaLy-Cell is authorized by the Department for Protection of Populations to manipulate tissues and cells of animal origin.

Safety, Handling and Storage

The products are distributed for research purposes only. They have not been approved for therapeutic or diagnostic purposes. Cryopreserved Hepatocytes should be stored in liquid nitrogen vapor (-150°C or colder). They should be thawed in accordance with our thawing protocol, which is provided with hepatocytes.

Animal hepatocytes qualified

for long-term culture

Our plateable cryopreserved animal hepatocyte lots are qualified for long-term culture, either as sandwich culture with a regular re-overlay of Matrigel, allowing them to be cultured up to 10 days and forming biliary canaliculi or as 3D spheroids up to 14 days.

Learn more about long-term 2D sandwich cultures on PubMed

Animal hepatocytes qualified for response

to CYP inducers

Our plateable cryopreserved animal hepatocyte lots are qualified for their concentration-dependent response to prototypical CYP and UGT inducers.